Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5323658 | 0.83 | USP30 (0.49) | USP30JAK3GPR119AAK1 | |
| SCHEMBL5323654 | 0.83 | USP30 (0.49) | USP30JAK3GPR119AAK1 | |
| SCHEMBL8225431 | 0.82 | USP30 (0.45) | USP30ROCK1JAK3AAK1 | |
| SCHEMBL903963 | 0.81 | USP30 (0.47) | USP30JAK3GPR119ALOX5APFEN1 | |
| SCHEMBL29912881 | 0.78 | GPR119 (0.47) | JAK3GPR119ALOX5APFEN1 | |
| SCHEMBL20893538 | 0.78 | USP30 (0.47) | USP30ROCK1BACE1BACE2GPR119 | |
| SCHEMBL31401504 | 0.74 | USP30 (0.49) | USP30BACE1BACE2AAK1 | |
| SCHEMBL10067776 | 0.74 | GPR119 (0.48) | GPR119 | |
| SCHEMBL30557632 | 0.74 | USP30 (0.44) | USP30BACE1BACE2AAK1DPP4 | |
| SCHEMBL26784127 | 0.74 | USP30 (0.44) | USP30BACE1BACE2AAK1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |