Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29912881 | 0.85 | GPR119 (0.47) | JAK3ALOX5APFEN1IDO1NR1H2 | |
| SCHEMBL1103975 | 0.81 | GPR119 (0.50) | DPP4ALOX5APFEN1IDO1SCN9A | |
| SCHEMBL903965 | 0.81 | USP30 (0.43) | USP30DPP4JAK3ALOX5APFEN1 | |
| SCHEMBL10067776 | 0.81 | GPR119 (0.48) | GPR119 | |
| SCHEMBL903936 | 0.80 | GPR119 (0.48) | GPR119 | |
| SCHEMBL20439309 | 0.79 | USP30 (0.52) | USP30DPP4IDO1NR1H2RORC | |
| SCHEMBL29912982 | 0.77 | SSTR4 (0.44) | USP30DPP4JAK3ALOX5APFEN1 | |
| SCHEMBL30785458 | 0.77 | SSTR4 (0.44) | USP30DPP4JAK3ALOX5APFEN1 | |
| SCHEMBL903835 | 0.77 | GPR119 (0.51) | GPR119 | |
| SCHEMBL23706204 | 0.75 | HCRTR1 (0.40) | JAK3ALOX5APFEN1RORCGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |