Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 8/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 10/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.45 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.45 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10068058 | 0.81 | GPR119 (0.47) | CHRNA7GPR119 | |
| SCHEMBL903901 | 0.80 | HDAC3 (0.41) | GPR119 | |
| SCHEMBL10068055 | 0.80 | HDAC3 (0.36) | CYP2D6GPR119 | |
| SCHEMBL10067703 | 0.78 | GPR119 (0.45) | CHRNA7CYP2D6GPR119 | |
| SCHEMBL903926 | 0.78 | GPR119 (0.47) | GPR119 | |
| SCHEMBL10067704 | 0.78 | GPR119 (0.45) | CHRNA7CYP2D6GPR119 | |
| SCHEMBL903982 | 0.78 | GPR119 (0.47) | GPR119 | |
| SCHEMBL904019 | 0.77 | GPR119 (0.46) | CHRNA7GPR119 | |
| SCHEMBL904171 | 0.77 | GPR119 (0.41) | CHRNA7GPR119 | |
| SCHEMBL904161 | 0.76 | GPR119 (0.45) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |