Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10068058 | 0.85 | GPR119 (0.47) | GPR119GPR183CYP11B1TP53CHRNA7 | |
| SCHEMBL903926 | 0.84 | GPR119 (0.47) | GPR119CYP11B1RAB9AMAPTL3MBTL1 | |
| SCHEMBL10067420 | 0.82 | GPR119 (0.47) | GPR119GPR183 | |
| SCHEMBL10067703 | 0.80 | GPR119 (0.45) | GPR119CYP11B1CHRNA7RAB9ANPC1 | |
| SCHEMBL10067704 | 0.80 | GPR119 (0.45) | GPR119CYP11B1CHRNA7RAB9ANPC1 | |
| SCHEMBL904116 | 0.78 | GPR119 (0.39) | GPR119 | |
| SCHEMBL903971 | 0.77 | CHRNA3 (0.47) | GPR119CHRNA7 | |
| SCHEMBL903901 | 0.76 | HDAC3 (0.41) | GPR119 | |
| SCHEMBL904171 | 0.74 | GPR119 (0.41) | GPR119CYP11B1CHRNA7 | |
| SCHEMBL903982 | 0.73 | GPR119 (0.47) | GPR119RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |