Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 8/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.34 |
| ▸ | DRD4 | P21917 | 4/20 | 0.32 |
| ▸ | DRD2 | P14416 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL904073 | 0.89 | GPR119 (0.36) | MKNK1MKNK2ACACBGPR119DRD4 | |
| SCHEMBL10067592 | 0.89 | GPR119 (0.36) | MKNK1MKNK2ACACBGPR119DRD4 | |
| SCHEMBL904041 | 0.89 | GPR119 (0.35) | MKNK1MKNK2ACACBGPR119DRD4 | |
| SCHEMBL904171 | 0.87 | GPR119 (0.41) | GPR119 | |
| SCHEMBL904032 | 0.85 | ACACB (0.37) | ACACBGPR119 | |
| SCHEMBL904069 | 0.81 | GPR119 (0.33) | MKNK1MKNK2ACACBGPR119 | |
| SCHEMBL904187 | 0.79 | MKNK1 (0.40) | MKNK1MKNK2 | |
| SCHEMBL10067579 | 0.76 | GPR119 (0.38) | GPR119 | |
| SCHEMBL904154 | 0.74 | GPR119 (0.33) | MKNK1MKNK2GPR119 | |
| SCHEMBL10067596 | 0.73 | GPR119 (0.49) | ACACBGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |