Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 4/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL904171 | 0.92 | GPR119 (0.41) | GPR119CYP11B1CYP11B2GRM2 | |
| SCHEMBL904073 | 0.88 | GPR119 (0.36) | ACACBGPR119CYP11B1CYP11B2GRM2 | |
| SCHEMBL10067592 | 0.88 | GPR119 (0.36) | ACACBGPR119CYP11B1CYP11B2GRM2 | |
| SCHEMBL904041 | 0.86 | GPR119 (0.35) | ACACBGPR119CYP11B1CYP11B2 | |
| SCHEMBL903979 | 0.85 | MKNK1 (0.35) | ACACBGPR119 | |
| SCHEMBL904072 | 0.82 | ACACB (0.33) | ACACBGPR119MEN1KMT2AGRM2 | |
| SCHEMBL10067579 | 0.82 | GPR119 (0.38) | GPR119 | |
| SCHEMBL904154 | 0.80 | GPR119 (0.33) | GPR119CYP11B1CYP11B2 | |
| SCHEMBL10068058 | 0.77 | GPR119 (0.47) | GPR119CYP11B1CYP11B2RAB9ATP53 | |
| SCHEMBL904187 | 0.76 | MKNK1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |