Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8506282 | 0.82 | HTR1D (0.44) | SLC6A4SLC6A2SLC6A3GABRA1GABRB2 | |
| SCHEMBL8878498 | 0.81 | HTR2A (0.38) | SLC6A4SLC6A2SLC6A3GABRA1GABRB2 | |
| SCHEMBL8878506 | 0.81 | HTR2A (0.38) | SLC6A4SLC6A2SLC6A3GABRA1GABRB2 | |
| SCHEMBL6969552 | 0.79 | SLC6A4 (0.33) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9373102 | 0.79 | HTR1B (0.39) | SLC6A4SLC6A2SLC6A3HTR6HTR1D | |
| SCHEMBL9373088 | 0.79 | HTR1B (0.39) | SLC6A4SLC6A2SLC6A3HTR6HTR1D | |
| SCHEMBL7665068 | 0.76 | HTR6 (0.54) | SLC6A4GABRA1GABRB2HTR6HTR1D | |
| SCHEMBL9236276 | 0.76 | HTR1B (0.54) | SLC6A2SLC6A3GABRA1GABRB2HTR6 | |
| SCHEMBL9236283 | 0.76 | HTR1B (0.54) | SLC6A2SLC6A3GABRA1GABRB2HTR6 | |
| SCHEMBL8208352 | 0.76 | HTR1D (0.40) | SLC6A4SLC6A2SLC6A3HTR6HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0695301-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-02-07 | — | — | EP | claimed |