Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9042862 | 0.83 | L3MBTL1 (0.50) | ALDH1A1KDM4EMAPTSIRT1DDB1 | |
| SCHEMBL9042389 | 0.82 | ALDH1A1 (0.47) | ALDH1A1KDM4ESIRT1POLBDDB1 | |
| SCHEMBL1832087 | 0.82 | ALDH1A1 (0.57) | ALDH1A1MAPTMEN1KMT2APKM | |
| SCHEMBL9043025 | 0.80 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTLMNAMEN1 | |
| SCHEMBL9040070 | 0.76 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTPOLBLMNA | |
| SCHEMBL9042517 | 0.76 | KDM4E (0.53) | ALDH1A1KDM4EMAPTLMNAMEN1 | |
| SCHEMBL9042146 | 0.75 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTPOLBMEN1 | |
| SCHEMBL9043598 | 0.75 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTPOLBMEN1 | |
| SCHEMBL14829199 | 0.75 | ALDH1A1 (0.69) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL2302022 | 0.75 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0553130-B1 | PYRROLIDINE DIONE DERIVATIVES | PFIZER (US) | 1996-01-03 | — | — | EP | claimed |
| EP-0553130-A1 | PYRROLIDINE DIONE DERIVATIVES. | PFIZER (US) | 1993-08-04 | — | — | EP | claimed |
| WO-1992006954-A2 | PYRROLIDINE DIONE DERIVATIVES | PFIZER INC. (US) | 1992-04-30 | — | — | WO | claimed |
| EP-0553130-B1 | PYRROLIDINE DIONE DERIVATIVES | PFIZER (US) | 1996-01-03 | — | — | EP | disclosed |
| EP-0553130-A1 | PYRROLIDINE DIONE DERIVATIVES. | PFIZER (US) | 1993-08-04 | — | — | EP | disclosed |
| WO-1992006954-A2 | PYRROLIDINE DIONE DERIVATIVES | PFIZER INC. (US) | 1992-04-30 | — | — | WO | disclosed |