Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038552 | 0.82 | PDE4B (0.45) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL9037540 | 0.79 | CYP3A4 (0.40) | ALDH1A1LMNACYP3A4TSHRPMP22 | |
| SCHEMBL9038148 | 0.76 | AURKA (0.49) | ADORA2AADORA2BALDH1A1LMNACYP3A4 | |
| SCHEMBL9037923 | 0.75 | TAS2R14 (0.46) | ADORA2AADORA2BALDH1A1LMNAADORA3 | |
| SCHEMBL10755461 | 0.75 | ADORA2A (0.39) | ADORA2AADORA2BALDH1A1LMNACYP3A4 | |
| SCHEMBL9037748 | 0.75 | AURKA (0.39) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL9039306 | 0.70 | PDE4B (0.43) | ADORA2AADORA2BCYP3A4TSHRADORA1 | |
| SCHEMBL9038556 | 0.68 | PDE4B (0.44) | ADORA2AADORA2BMAPTTSHRBLM | |
| SCHEMBL9038040 | 0.68 | PDE4B (0.43) | ADORA2AADORA2B | |
| SCHEMBL12615534 | 0.67 | CYP3A4 (0.45) | ADORA2AADORA2BALDH1A1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696590-A1 | Pyrido[2,3-d]pyrimidine derivatives, their preparation and their use as anti-asthma agents | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-02-14 | — | — | EP | disclosed |