Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587355 | 0.77 | HTT (0.33) | TDP1KDM4ESMN1; SMN2 | |
| SCHEMBL3587360 | 0.77 | HTT (0.33) | TDP1KDM4ESMN1; SMN2 | |
| SCHEMBL3053937 | 0.72 | NR2E1 (0.33) | ADRA1A | |
| SCHEMBL7777047 | 0.69 | LMNA (0.38) | LMNACNR1ADRA1ATDP1KDM4E | |
| SCHEMBL1559904 | 0.69 | ADRB2 (0.32) | — | |
| SCHEMBL1559905 | 0.69 | ADRB2 (0.32) | — | |
| SCHEMBL1559885 | 0.68 | — | — | |
| SCHEMBL1559880 | 0.68 | — | — | |
| SCHEMBL17929828 | 0.68 | — | — | |
| SCHEMBL7290876 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0402989-B1 | Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones | JANSSEN PHARMACEUTICA NV (BE) | 1996-04-03 | — | — | EP | disclosed |
| US-5075309-A | For prevention and treatment of fungal diseases in mammals | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-24 | — | — | US | disclosed |
| EP-0402989-A2 | Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-12-19 | — | — | EP | disclosed |