Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044216 | 0.73 | MAPK1 (0.69) | MAPK1SMN1; SMN2L3MBTL1SIGMAR1CHRM2 | |
| SCHEMBL11631477 | 0.71 | MAPK1 (0.58) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM4 | |
| SCHEMBL11559170 | 0.70 | MAPK1 (0.51) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM4 | |
| SCHEMBL8709456 | 0.70 | MAPK1 (0.72) | MAPK1SMN1; SMN2L3MBTL1HTR2AHTR2C | |
| SCHEMBL13921299 | 0.69 | MAPK1 (0.82) | MAPK1SMN1; SMN2L3MBTL1SIGMAR1HTR2A | |
| SCHEMBL10409949 | 0.69 | MAPK1 (0.79) | MAPK1SMN1; SMN2L3MBTL1HTR2AHTR2B | |
| SCHEMBL11521605 | 0.69 | MAPK1 (0.79) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM4 | |
| SCHEMBL11204393 | 0.68 | MAPK1 (0.68) | MAPK1SMN1; SMN2L3MBTL1SIGMAR1CHRM2 | |
| SCHEMBL7142067 | 0.68 | MAPK1 (0.64) | MAPK1SMN1; SMN2L3MBTL1SIGMAR1CHRM2 | |
| SCHEMBL9039655 | 0.67 | MAPK1 (0.72) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0339978-B1 | Fused polycyclic compounds, compositions, methods of manufacture, and their use as PAF antagonists, antihistamines and/or antiinflammatory agents | SCHERING CORP (US) | 1996-08-21 | — | — | EP | disclosed |
| EP-0412988-A1 | FUSED POLYCYCLIC COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND THEIR USE AS PAF ANTAGONISTS, ANTIHISTAMINES AND/OR ANTIINFLAMMATORY AGENTS | SCHERING CORPORATION (US) | 1991-02-20 | — | — | EP | disclosed |
| EP-0339978-A1 | Fused polycyclic compounds, compositions, methods of manufacture, and their use as PAF antagonists, antihistamines and/or antiinflammatory agents | SCHERING CORPORATION (US) | 1989-11-02 | — | — | EP | disclosed |
| WO-1989010363-A1 | FUSED POLYCYCLIC COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND THEIR USE AS PAF ANTAGONISTS, ANTIHISTAMINES AND/OR ANTIINFLAMMATORY AGENTS | SCHERING CORPORATION (US) | 1989-11-02 | — | — | WO | disclosed |