Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13921299 | 0.78 | MAPK1 (0.82) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM3 | |
| SCHEMBL11521605 | 0.75 | MAPK1 (0.79) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM3 | |
| SCHEMBL10409949 | 0.75 | MAPK1 (0.79) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM3 | |
| SCHEMBL14430479 | 0.74 | MAPK1 (0.61) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM3 | |
| SCHEMBL11204393 | 0.74 | MAPK1 (0.68) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM3 | |
| SCHEMBL8709456 | 0.74 | MAPK1 (0.72) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM3 | |
| SCHEMBL11883256 | 0.74 | MAPK1 (0.64) | MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9631976 | 0.73 | MAPK1 (0.73) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM3 | |
| SCHEMBL2151191 | 0.72 | MAPK1 (0.77) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM3 | |
| SCHEMBL9044216 | 0.72 | MAPK1 (0.69) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0339978-B1 | Fused polycyclic compounds, compositions, methods of manufacture, and their use as PAF antagonists, antihistamines and/or antiinflammatory agents | SCHERING CORP (US) | 1996-08-21 | — | — | EP | disclosed |
| EP-0412988-A1 | FUSED POLYCYCLIC COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND THEIR USE AS PAF ANTAGONISTS, ANTIHISTAMINES AND/OR ANTIINFLAMMATORY AGENTS | SCHERING CORPORATION (US) | 1991-02-20 | — | — | EP | disclosed |
| EP-0339978-A1 | Fused polycyclic compounds, compositions, methods of manufacture, and their use as PAF antagonists, antihistamines and/or antiinflammatory agents | SCHERING CORPORATION (US) | 1989-11-02 | — | — | EP | disclosed |
| WO-1989010363-A1 | FUSED POLYCYCLIC COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE AND THEIR USE AS PAF ANTAGONISTS, ANTIHISTAMINES AND/OR ANTIINFLAMMATORY AGENTS | SCHERING CORPORATION (US) | 1989-11-02 | — | — | WO | disclosed |