Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 6/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | ABL2 | P42684 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045521 | 0.85 | EGFR (0.43) | KDM4EALDH1A1HPGDLMNAMAPT | |
| SCHEMBL9041707 | 0.85 | HPGDS (0.41) | KDM4EALDH1A1LMNAMAPTNPC1 | |
| SCHEMBL9044118 | 0.85 | EGFR (0.43) | BRD4KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL9041822 | 0.85 | EGFR (0.43) | ALDH1A1MEN1LMNAMAPTKMT2A | |
| SCHEMBL9040418 | 0.84 | KDM4E (0.40) | KDM4EALDH1A1LMNANPC1RAB9A | |
| SCHEMBL9043615 | 0.82 | IDO1 (0.40) | KDM4EALDH1A1HPGDMEN1LMNA | |
| SCHEMBL8774614 | 0.82 | GAA (0.49) | BRD4KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL9041842 | 0.81 | FGFR2 (0.44) | KDM4EALDH1A1HPGDMEN1LMNA | |
| SCHEMBL9042579 | 0.76 | MAOA (0.41) | BRD4KDM4EALDH1A1MEN1MAPT | |
| SCHEMBL9043690 | 0.74 | CUL4A (0.43) | KDM4EALDH1A1HPGDMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738717-A1 | Certain substituted pyrimidines as intermediates for production of cycloalkyl and azacycloalkyl pyrrolopyrimidines | NEUROGEN CORPORATION (US) | 1996-10-23 | — | — | EP | claimed |
| EP-0552237-A1 | CERTAIN CYCLOALKYL AND AZACYCLOALKYL PYRROLOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1993-07-28 | — | — | EP | claimed |
| WO-1992006094-A1 | CERTAIN CYCLOALKYL AND AZACYCLOALKYL PYRROLOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1992-04-16 | — | — | WO | claimed |
| US-5585490-A | DIANGOSIS AND TREATMENT OF ANXIETY, SLEEP, AND SEIZURE DISORDERS | NEUROGEN CORPORATION (US) | 1996-12-17 | — | — | US | disclosed |
| EP-0738717-A1 | Certain substituted pyrimidines as intermediates for production of cycloalkyl and azacycloalkyl pyrrolopyrimidines | NEUROGEN CORPORATION (US) | 1996-10-23 | — | — | EP | disclosed |