Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.51 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9042834 | 0.95 | AGTR1 (0.50) | AGTR1AGTR2ENPP2ALDH1A1MEN1 | |
| SCHEMBL9587177 | 0.91 | AGTR1 (0.51) | AGTR1AGTR2ENPP2ALDH1A1MEN1 | |
| SCHEMBL9040254 | 0.88 | AGTR1 (0.53) | AGTR1AGTR2ENPP2ALDH1A1MEN1 | |
| SCHEMBL9041645 | 0.87 | AGTR1 (0.48) | AGTR1AGTR2ENPP2ALDH1A1MEN1 | |
| SCHEMBL9040417 | 0.87 | AGTR2 (0.46) | AGTR1AGTR2 | |
| SCHEMBL9040281 | 0.86 | AGTR1 (0.52) | AGTR1AGTR2ENPP2ALDH1A1MEN1 | |
| SCHEMBL9039407 | 0.84 | AGTR1 (0.52) | AGTR1AGTR2ENPP2ALDH1A1MEN1 | |
| SCHEMBL8972164 | 0.82 | AGTR1 (0.60) | AGTR1AGTR2ENPP2ALDH1A1 | |
| SCHEMBL8972529 | 0.82 | AGTR1 (0.62) | AGTR1AGTR2ENPP2 | |
| SCHEMBL9041166 | 0.81 | AGTR2 (0.51) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0480204-B1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-03-20 | — | — | EP | disclosed |
| US-5215994-A | Treating or preventing hypertension or heart failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-01 | — | — | US | disclosed |
| US-5210092-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-11 | — | — | US | disclosed |
| EP-0480204-A1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |