SCHEMBL9040916

SCHEMBL9040916

CCCc1c(O)c(C)c(C(=O)O)c(C)c1O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LDHA P00338 4/20 0.53
LDHB P07195 4/20 0.53
FASN P49327 1/20 0.42
PTPN1 P18031 1/20 0.42
PTPN11 Q06124 1/20 0.42
FFAR1 O14842 1/20 0.40
JUN P05412 1/20 0.36
PLA2G2A P14555 1/20 0.35
PLA2G5 P39877 1/20 0.35
PRKCI P41743 1/20 0.34
HCAR2 Q8TDS4 1/20 0.34
BID P55957 3/20 0.34
MCL1 Q07820 3/20 0.34
BCL2L1 Q07817 2/20 0.34
BAK1 Q16611 2/20 0.34
KAT8 Q9H7Z6 2/20 0.34
PPARG P37231 1/20 0.34
PPARA Q07869 1/20 0.34
EP300 Q09472 1/20 0.34
KAT2A Q92830 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28656372 0.84 LDHA (0.50) LDHALDHBFASNPTPN1PTPN11
SCHEMBL4122794 0.84 LDHA (0.50) LDHALDHBFASNPTPN1PTPN11
SCHEMBL5850910 0.80 LDHA (0.54) LDHALDHBFASNPTPN1PTPN11
SCHEMBL19611141 0.80 LDHA (0.50) LDHALDHBFASNPTPN1PTPN11
SCHEMBL5588178 0.80 LDHA (0.54) LDHALDHBFASNPTPN1PTPN11
SCHEMBL14989236 0.77 LDHA (0.48) LDHALDHBPTPN1PTPN11JUN
SCHEMBL22418967 0.77 LDHA (0.48) LDHALDHBPTPN1PTPN11JUN
SCHEMBL14031682 0.77 LDHA (0.46) LDHALDHBPTPN1PTPN11JUN
SCHEMBL31643874 0.77 FASN (0.39) LDHALDHBFASNPTPN1PTPN11
SCHEMBL15841763 0.77 LDHA (0.59) LDHALDHBPTPN1PTPN11FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0535192-B1 NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME HOFFMANN LA ROCHE (CH) 1996-06-19 EP disclosed
US-5486466-A ENZYME INHIBITORS HOFFMANN-LA ROCHE INC. (US) 1996-01-23 US disclosed
US-5399741-A DNA gyrase inhibitors, process for their manufacture and pharmaceutical preparations containing same HOFFMANN-LA ROCHE INC. (US) 1995-03-21 US disclosed
US-5294609-A Microbiocides HOFFMANN-LAROCHE INC. (US) 1994-03-15 US disclosed
EP-0535192-A1 NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME. HOFFMANN LA ROCHE (CH) 1993-04-07 EP disclosed
WO-1992018490-A1 NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME F. HOFFMANN-LA ROCHE AG (CH) 1992-10-29 WO disclosed