Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9041053 | 0.91 | AGTR2 (0.38) | AGTR1AGTR2HTR6 | |
| SCHEMBL9039769 | 0.88 | AGTR2 (0.45) | AGTR1AGTR2 | |
| SCHEMBL9041470 | 0.88 | AGTR1 (0.36) | AGTR1AGTR2NOS1NOS2HTR6 | |
| SCHEMBL9042800 | 0.83 | AGTR2 (0.41) | AGTR1AGTR2 | |
| SCHEMBL9040058 | 0.83 | AGTR2 (0.41) | AGTR1AGTR2 | |
| SCHEMBL9041271 | 0.83 | AGTR2 (0.50) | AGTR1AGTR2 | |
| SCHEMBL9041886 | 0.82 | AGTR2 (0.41) | AGTR1AGTR2 | |
| SCHEMBL9854231 | 0.81 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL9040417 | 0.80 | AGTR2 (0.46) | AGTR1AGTR2 | |
| SCHEMBL9043514 | 0.78 | AGTR1 (0.35) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0480204-B1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-03-20 | — | — | EP | disclosed |
| US-5215994-A | Treating or preventing hypertension or heart failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-01 | — | — | US | disclosed |
| US-5210092-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-11 | — | — | US | disclosed |
| EP-0480204-A1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |