Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.49 |
| ▸ | GPR183 | P32249 | 1/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 3/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10067596 | 1.00 | GPR119 (0.49) | GPR119GPR183NR1H2NR1H3ACACB | |
| SCHEMBL904120 | 0.89 | GPR119 (0.48) | GPR119GPR183NR1H2NR1H3PTGS1 | |
| SCHEMBL10067420 | 0.83 | GPR119 (0.47) | GPR119GPR183 | |
| SCHEMBL904179 | 0.83 | GPR119 (0.59) | GPR119GPR183 | |
| SCHEMBL904068 | 0.82 | GPR119 (0.46) | GPR119GPR183NR1H2NR1H3PTGS1 | |
| SCHEMBL10067575 | 0.81 | GPR119 (0.47) | GPR119GPR183PTGS1PTGS2CYP4F2 | |
| SCHEMBL904051 | 0.80 | GPR119 (0.51) | GPR119GPR183PTGS1PTGS2CYP4F2 | |
| SCHEMBL904178 | 0.79 | GPR183 (0.48) | GPR119GPR183PTGS1PTGS2CYP4F2 | |
| SCHEMBL903995 | 0.78 | GPR119 (0.45) | GPR119GPR183PTGS1PTGS2CYP4F2 | |
| SCHEMBL903874 | 0.78 | GPR119 (0.45) | GPR119GPR183PTGS2CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |