Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10068006 | 0.91 | GPR119 (0.45) | GPR119GPR183PTGS2MMP13CYP4F2 | |
| SCHEMBL904192 | 0.82 | GPR119 (0.49) | GPR119GPR183PTGS1PTGS2CYP4F2 | |
| SCHEMBL10067596 | 0.82 | GPR119 (0.49) | GPR119GPR183PTGS1PTGS2CYP4F2 | |
| SCHEMBL10067768 | 0.78 | GPR119 (0.47) | GPR119GPR183 | |
| SCHEMBL10067770 | 0.78 | GPR119 (0.45) | GPR119GPR183 | |
| SCHEMBL904069 | 0.77 | GPR119 (0.33) | GPR119 | |
| SCHEMBL10068007 | 0.75 | GPR119 (0.52) | GPR119 | |
| SCHEMBL904109 | 0.74 | GPR119 (0.45) | GPR119 | |
| SCHEMBL903924 | 0.73 | GPR119 (0.53) | GPR119 | |
| SCHEMBL903917 | 0.72 | GPR119 (0.60) | GPR119GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |