SCHEMBL9044161

SCHEMBL9044161

COc1cc2cnc(N3CCc4cc([N+](=O)[O-])ccc43)nc2cc1OC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
LMNA P02545 3/20 0.47
MAPT P10636 3/20 0.47
MAPK1 P28482 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
HTT P42858 2/20 0.47
PDGFRB P09619 1/20 0.46
PDGFRA P16234 1/20 0.46
ROCK1 Q13464 1/20 0.41
ACHE P22303 1/20 0.40
BACE1 P56817 1/20 0.40
KDM4E B2RXH2 1/20 0.40
POLB P06746 1/20 0.40
GAA P10253 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
EGFR P00533 2/20 0.39
KIT P10721 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
CSF1R P07333 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8649221 0.92 ROCK1 (0.50) ALDH1A1LMNAMAPTMAPK1SMN1; SMN2
SCHEMBL27479086 0.82 CYP1A2 (0.46) ALDH1A1LMNAMAPTMAPK1SMN1; SMN2
SCHEMBL3303857 0.78 MAPT (0.46) ALDH1A1LMNAMAPTMAPK1SMN1; SMN2
SCHEMBL8647897 0.78 EGFR (0.67) ALDH1A1LMNAMAPTMAPK1SMN1; SMN2
SCHEMBL5245531 0.78 ALDH1A1 (0.47) ALDH1A1LMNAMAPTMAPK1SMN1; SMN2
SCHEMBL31554510 0.77 ALDH1A1 (0.45) ALDH1A1LMNAMAPTMAPK1SMN1; SMN2
SCHEMBL31554509 0.77 ALDH1A1 (0.45) ALDH1A1LMNAMAPTMAPK1SMN1; SMN2
SCHEMBL3016231 0.74 ROCK1 (0.54) ALDH1A1LMNASMN1; SMN2HTTROCK1
SCHEMBL3294743 0.73 ROCK1 (0.51) ALDH1A1LMNAMAPTMAPK1SMN1; SMN2
SCHEMBL5756449 0.72 MAPT (0.49) ALDH1A1LMNAMAPTMAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0746554-A1 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS PFIZER INC. (US) 1996-12-11 EP disclosed
WO-1995023141-A1 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS PFIZER INC. (US) 1995-08-31 WO disclosed