Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044597 | 0.88 | HCRTR1 (0.35) | HCRTR1HCRTR2KDM4EALDH1A1HTT | |
| SCHEMBL9043406 | 0.87 | POLB (0.35) | HCRTR1HCRTR2KDM4EALDH1A1HTT | |
| SCHEMBL9046054 | 0.86 | ALDH1A1 (0.32) | HCRTR1HCRTR2ALDH1A1HTTHPGD | |
| SCHEMBL27311061 | 0.77 | POLB (0.35) | HCRTR1HCRTR2KDM4EALDH1A1HTT | |
| SCHEMBL9043112 | 0.77 | ADORA2A (0.37) | KDM4EALDH1A1HTTHPGDADORA2A | |
| SCHEMBL8987728 | 0.77 | POLB (0.38) | HCRTR1HCRTR2KDM4EALDH1A1HTT | |
| SCHEMBL9045189 | 0.75 | ALDH1A1 (0.33) | HCRTR1HCRTR2ALDH1A1HTTHPGD | |
| SCHEMBL9043151 | 0.75 | HTT (0.34) | KDM4EALDH1A1HTTHPGDADORA2A | |
| SCHEMBL8346329 | 0.74 | MAPT (0.34) | HCRTR1HCRTR2KDM4EALDH1A1HTT | |
| SCHEMBL9043647 | 0.73 | MAPT (0.32) | HCRTR1HCRTR2ALDH1A1HTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358609-B1 | Parasiticide compounds | CIBA GEIGY AG (CH) | 1996-07-24 | — | — | EP | claimed |
| US-5175293-A | Substituted 2-aminopyrimidine derivatives | CIBA-GEIGY CORPORATION (US) | 1992-12-29 | — | — | US | disclosed |