Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10489819 | 0.86 | KMT2A (0.63) | KMT2AMEN1ALDH1A1HPGDNPC1 | |
| SCHEMBL19805148 | 0.83 | MEN1 (0.68) | KMT2AMEN1ALDH1A1HPGDNPC1 | |
| SCHEMBL31126834 | 0.83 | KDM4E (0.68) | KMT2AMEN1ALDH1A1HPGDHTT | |
| SCHEMBL2860044 | 0.83 | KDM4E (0.68) | KMT2AMEN1ALDH1A1HPGDHTT | |
| SCHEMBL28401182 | 0.82 | ALDH1A1 (0.72) | KMT2AMEN1ALDH1A1HPGDNPC1 | |
| SCHEMBL4474267 | 0.81 | CYP1A2 (0.74) | KMT2AMEN1ALDH1A1HPGDHTT | |
| SCHEMBL11421007 | 0.81 | MEN1 (0.62) | KMT2AMEN1ALDH1A1HPGDNPC1 | |
| SCHEMBL10807728 | 0.81 | MEN1 (0.62) | KMT2AMEN1ALDH1A1HPGDNPC1 | |
| SCHEMBL9493549 | 0.81 | ALDH1A1 (0.54) | KMT2AMEN1ALDH1A1HPGDNPC1 | |
| SCHEMBL6655128 | 0.80 | MAPK13 (0.57) | KMT2AMEN1ALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640088-B1 | NOVEL TRICYCLIC THIAZOLO AND THIAZINO DERIVATIVES AND ANTI-VIRAL MEDICAMENTS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1996-10-09 | — | — | EP | disclosed |
| EP-0640087-A1 | USE OF TRICYCLIC PYRIMIDINE DERIVATIVES AS ANTI-VIRAL MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1995-03-01 | — | — | EP | disclosed |
| EP-0640088-A1 | NOVEL TRICYCLIC THIAZOLO AND THIAZINO DERIVATIVES AND ANTI-VIRAL MEDICAMENTS CONTAINING THEM. | BOEHRINGER MANNHEIM GMBH (DE) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023407-A1 | NOVEL TRICYCLIC THIAZOLO AND THIAZINO DERIVATIVES AND ANTI-VIRAL MEDICAMENTS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1993-11-25 | — | — | WO | disclosed |
| WO-1993023405-A1 | USE OF TRICYCLIC PYRIMIDINE DERIVATIVES AS ANTI-VIRAL MEDICAMENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1993-11-25 | — | — | WO | disclosed |