Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGT | P01019 | 2/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9142863 | 0.84 | AGTR1 (0.46) | AGTAGTR1AGTR2 | |
| SCHEMBL9247811 | 0.82 | AGTR1 (0.47) | AGTAGTR1AGTR2 | |
| SCHEMBL9044849 | 0.81 | BRS3 (0.45) | AGTR1AGTR2 | |
| SCHEMBL9044274 | 0.80 | AGT (0.51) | AGTAGTR1AGTR2TLR7 | |
| SCHEMBL9042308 | 0.79 | AGTR1 (0.49) | AGTAGTR1AGTR2 | |
| SCHEMBL9053263 | 0.77 | AGTR1 (0.49) | AGTAGTR1AGTR2 | |
| SCHEMBL839523 | 0.77 | CD274 (0.51) | AGTAGTR1AGTR2AKT1 | |
| SCHEMBL9140681 | 0.77 | AGTR1 (0.46) | AGTAGTR1AGTR2 | |
| SCHEMBL4566052 | 0.76 | AGTR1 (0.40) | AGTAGTR1AGTR2AKT1 | |
| SCHEMBL7312346 | 0.76 | AGT (0.46) | AGTAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0531876-B1 | Imidazoindolizine derivatives and process for preparation thereof | TANABE SEIYAKU CO (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5424316-A | Imidazopyridine derivatives for the treatment of hypertension | TANABE SEIYAKU CO., LTD. (JP) | 1995-06-13 | — | — | US | disclosed |
| US-5409936-A | Useful in prophylaxix; exhibits potent angiotensin ii inhibitory acivities | TANABE SEIYAKU CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0531876-A2 | Imidazoindolizine derivatives and process for preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |
| EP-0531874-A1 | Imidazopyridine derivatives and process for preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |