Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 3/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8992385 | 0.84 | AGTR1 (0.48) | BRS3AGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL9044276 | 0.81 | AGT (0.43) | AGTR1AGTR2 | |
| SCHEMBL9045987 | 0.79 | ACHE (0.42) | BRS3AGTR1AGTR2ACHE | |
| SCHEMBL9302701 | 0.76 | BRS3 (0.45) | BRS3AGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL9043004 | 0.76 | BRS3 (0.42) | BRS3AGTR1AGTR2ACHE | |
| SCHEMBL9044845 | 0.76 | AGTR1 (0.51) | AGTR1AGTR2ACHE | |
| SCHEMBL8979814 | 0.74 | AGTR1 (0.48) | BRS3AGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL9054292 | 0.73 | ACHE (0.44) | BRS3AGTR1AGTR2ACHE | |
| SCHEMBL9136676 | 0.73 | AGTR1 (0.49) | BRS3AGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL9303312 | 0.72 | BRS3 (0.38) | BRS3AGTR1AGTR2ACHEBDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0531876-B1 | Imidazoindolizine derivatives and process for preparation thereof | TANABE SEIYAKU CO (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5424316-A | Imidazopyridine derivatives for the treatment of hypertension | TANABE SEIYAKU CO., LTD. (JP) | 1995-06-13 | — | — | US | disclosed |
| US-5409936-A | Useful in prophylaxix; exhibits potent angiotensin ii inhibitory acivities | TANABE SEIYAKU CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| US-5268377-A | Imidazoindolizine derivatives process for preparation thereof and use thereof to treat hypertension | TANABE SEIYAKU CO., LTD. (JP) | 1993-12-07 | — | — | US | disclosed |
| EP-0531876-A2 | Imidazoindolizine derivatives and process for preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |
| EP-0531874-A1 | Imidazopyridine derivatives and process for preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |