Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12496111 | 0.80 | MAPT (0.54) | ADKMAPTLMNAMEN1KMT2A | |
| SCHEMBL9047230 | 0.80 | ALDH1A1 (0.51) | ADKMAPTLMNACYP1A2ALDH1A1 | |
| SCHEMBL9046792 | 0.77 | KDM1A (0.56) | ADKMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9046762 | 0.76 | MEN1 (0.68) | MAPTLMNAADORA3MEN1KMT2A | |
| SCHEMBL27833684 | 0.74 | NPC1 (0.45) | ADKMAPTLMNAADORA3MEN1 | |
| SCHEMBL4063214 | 0.73 | MAPT (0.47) | ADKMAPTLMNAKMT2ACYP1A2 | |
| SCHEMBL4338065 | 0.73 | CSF1R (0.52) | MAPTLMNAADORA3MEN1KMT2A | |
| SCHEMBL5349645 | 0.73 | MMP2 (0.47) | MAPTADORA3MEN1KMT2AALDH1A1 | |
| SCHEMBL11222729 | 0.73 | IDO1 (0.47) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL16229339 | 0.73 | MAPT (0.40) | MAPTLMNAMEN1KMT2AAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |