Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044545 | 0.86 | KDM4E (0.57) | HPGDHSD17B10NPC1RAB9AMEN1 | |
| SCHEMBL3516933 | 0.86 | HPGD (0.56) | HPGDHSD17B10NPC1RAB9AMEN1 | |
| SCHEMBL9043908 | 0.85 | MAPT (0.49) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL9046046 | 0.84 | KMT2A (0.46) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL9044585 | 0.84 | TOP2A (0.61) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL9046763 | 0.84 | EGFR (0.55) | HPGDNPC1RAB9AMEN1KMT2A | |
| SCHEMBL9045112 | 0.82 | FEN1 (0.51) | HPGDNPC1RAB9AMAPTTP53 | |
| SCHEMBL9046358 | 0.82 | KDM4E (0.48) | HPGDHSD17B10NPC1RAB9AMEN1 | |
| SCHEMBL9043358 | 0.82 | RAB9A (0.60) | HPGDHSD17B10NPC1RAB9AMEN1 | |
| SCHEMBL9047155 | 0.81 | MEN1 (0.56) | HPGDNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452873-B1 | 1,8-Naphthyridin-2-one derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-07-03 | — | — | EP | disclosed |
| US-5126341-A | Treatment of rheumarthritis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-06-30 | — | — | US | disclosed |
| EP-0452873-A1 | 1,8-Naphthyridin-2-one derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-10-23 | — | — | EP | disclosed |