Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9267903 | 0.89 | GABRA1 (0.33) | GABRA1GABRB2CA2 | |
| SCHEMBL9046662 | 0.86 | CA2 (0.41) | GABRA1GABRB2CA2 | |
| SCHEMBL199686 | 0.84 | GABRA1 (0.43) | GABRA1GABRB2TAAR1HTR1A | |
| SCHEMBL9044072 | 0.81 | GABRA1 (0.46) | GABRA1GABRB2CA2NLRP3 | |
| SCHEMBL9048354 | 0.81 | GABRA1 (0.36) | GABRA1GABRB2CA2POLB | |
| SCHEMBL9047350 | 0.79 | GABRA1 (0.39) | GABRA1GABRB2POLBTAAR1HTR1A | |
| SCHEMBL11141250 | 0.79 | CA2 (0.39) | GABRA1GABRB2CA2 | |
| SCHEMBL11143792 | 0.79 | CA2 (0.39) | GABRA1GABRB2CA2 | |
| SCHEMBL9045727 | 0.78 | CA2 (0.35) | GABRA1GABRB2CA2TAAR1 | |
| SCHEMBL9046947 | 0.78 | TAAR1 (0.37) | GABRA1GABRB2CA2POLBTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | claimed |
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | disclosed |
| EP-0664802-A1 | N-ARYLHETEROARYLALKYL 1-PHENYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1995-08-02 | — | — | EP | disclosed |