Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
| ▸ | ECE1 | P42892 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044938 | 0.83 | POLB (0.39) | POLBCYP2D6CYP2C9GRIN2BKDM4E | |
| SCHEMBL7143079 | 0.80 | CPT2 (0.47) | POLBPREPKDM4ELMNA | |
| SCHEMBL7138322 | 0.76 | POLB (0.42) | POLBPREPKDM4ELMNAACE2 | |
| SCHEMBL7142747 | 0.75 | POLB (0.41) | POLBPREPKDM4ELMNAACE2 | |
| SCHEMBL7149001 | 0.75 | POLB (0.41) | POLBPREPKDM4ELMNAECE1 | |
| SCHEMBL7143386 | 0.74 | POLB (0.41) | POLBPREP | |
| SCHEMBL17424350 | 0.73 | GRIN2B (0.41) | POLBGRIN2B | |
| SCHEMBL7144595 | 0.73 | POLB (0.48) | POLBPREPKDM4ELMNAACE2 | |
| SCHEMBL7150010 | 0.72 | POLB (0.47) | POLBPREPKDM4ELMNA | |
| SCHEMBL20315235 | 0.71 | PSEN1 (0.45) | POLBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0551993-B1 | Pyrrolidine derivatives and process for preparing the same | SUMITOMO PHARMA (JP) | 1996-07-10 | — | — | EP | disclosed |
| US-5322952-A | Pyrrolidine derivatives and process for preparing the same | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-06-21 | — | — | US | disclosed |
| EP-0551993-A1 | Pyrrolidine derivatives and process for preparing the same | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1993-07-21 | — | — | EP | disclosed |