Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047855 | 0.79 | AR (0.47) | SMN1; SMN2ARDAOPNPNR3C1 | |
| SCHEMBL9046955 | 0.79 | PNP (0.38) | SMN1; SMN2MEN1KMT2APARP1MAPT | |
| SCHEMBL2178053 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2ARDAOKDM4ELMNA | |
| SCHEMBL14434857 | 0.69 | CYP1A2 (0.41) | SMN1; SMN2PARP1KDM4ELMNAPNP | |
| SCHEMBL6425337 | 0.68 | GRIN1 (0.39) | MEN1KMT2AKDM4E | |
| SCHEMBL7305815 | 0.68 | PARP1 (0.42) | SMN1; SMN2PARP1AURKADAPK3JAK2 | |
| SCHEMBL14728509 | 0.67 | AR (0.42) | SMN1; SMN2ARPNPIDO1 | |
| SCHEMBL5178271 | 0.67 | ALDH1A1 (0.50) | SMN1; SMN2IDO1 | |
| SCHEMBL15844018 | 0.66 | DAO (0.54) | SMN1; SMN2ARDAOKDM4ELMNA | |
| SCHEMBL2673325 | 0.66 | TYMP (0.66) | SMN1; SMN2ARDAOKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| EP-0713487-A1 | NOVEL QUINOLONE CARBOXYLIC ACID DERIVATIVES | DONG WHA PHARMACEUTICAL INDUSTRIAL CO. LTD. (KR) | 1996-05-29 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |