Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | PNP | P00491 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | QPCT | Q16769 | 1/20 | 0.38 |
| ▸ | BRS3 | P32247 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045170 | 0.79 | SMN1; SMN2 (0.48) | ARPNPNR3C1SMN1; SMN2DAO | |
| SCHEMBL9046955 | 0.78 | PNP (0.38) | PNPSMN1; SMN2POLBTSHR | |
| SCHEMBL15846218 | 0.74 | IP6K1 (0.44) | ARPNPIDH1POLBTDP1 | |
| SCHEMBL7296430 | 0.73 | HTT (0.40) | SMN1; SMN2POLBTDP1TP53TSHR | |
| SCHEMBL8323254 | 0.70 | HAO1 (0.42) | PNPSMN1; SMN2POLB | |
| SCHEMBL20212358 | 0.70 | HTR6 (0.51) | PNPSMN1; SMN2 | |
| SCHEMBL2090430 | 0.69 | IDO1 (0.53) | CNR2 | |
| SCHEMBL3296809 | 0.68 | IDO1 (0.61) | SMN1; SMN2CNR2 | |
| SCHEMBL11449203 | 0.67 | IDO1 (0.47) | ARPNPNR3C1TDP1CNR2 | |
| SCHEMBL11450223 | 0.67 | LMNA (0.52) | ARPNPNR3C1SMN1; SMN2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |