Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 5/20 | 0.49 |
| ▸ | HTR1B | P28222 | 5/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR1E | P28566 | 1/20 | 0.49 |
| ▸ | HTR1F | P30939 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR5A | P47898 | 1/20 | 0.49 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Avitriptan SCHEMBL29633456 | 0.95 | HTR1D (0.55) | HTR1DHTR1BHTR2AHTR1AHTR7 | |
| Avitriptan SCHEMBL147315 | 0.95 | HTR1D (0.55) | HTR1DHTR1BHTR2AHTR1AHTR7 | |
| Avitriptan SCHEMBL4352074 | 0.95 | HTR1D (0.54) | HTR1DHTR1BHTR2AHTR1AHTR7 | |
| SCHEMBL4349219 | 0.86 | HTR1A (0.49) | HTR1AHTR7SLC6A4KCNH2 | |
| SCHEMBL6363083 | 0.86 | HTR1A (0.49) | HTR1AHTR7SLC6A4KCNH2 | |
| SCHEMBL4346029 | 0.85 | HTR1A (0.48) | HTR1DHTR1BHTR1AHTR7SLC6A4 | |
| Avitriptan SCHEMBL18396454 | 0.85 | HTR1A (0.57) | HTR1DHTR1BHTR2AHTR1AHTR7 | |
| SCHEMBL4345058 | 0.84 | HTR1A (0.47) | HTR1AHTR7SLC6A4KCNH2 | |
| SCHEMBL6362007 | 0.84 | HTR1D (0.51) | HTR1DHTR1BHTR2AHTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL4349599 | 0.83 | HTR1A (0.48) | HTR1AHTR7SLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714896-A1 | INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF MIGRAINE, COMPOSITION AND UTILIZATION | VITA-INVEST, S.A. (ES) | 1996-06-05 | — | — | EP | disclosed |