Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046887 | 0.82 | TAAR1 (0.39) | TAAR1SMN1; SMN2PKMHTTKDM4E | |
| SCHEMBL14959685 | 0.80 | TAAR1 (0.63) | TAAR1GAAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9046829 | 0.79 | EED (0.40) | TAAR1SMN1; SMN2KDM4E | |
| SCHEMBL9044815 | 0.79 | TAAR1 (0.37) | TAAR1GAASMN1; SMN2HTTKDM4E | |
| SCHEMBL27749394 | 0.79 | MEN1 (0.62) | TAAR1GAAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2222708 | 0.78 | TAAR1 (0.78) | TAAR1GAAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9045988 | 0.78 | GABRA1 (0.34) | TAAR1KMT2ASMN1; SMN2MEN1KDM4E | |
| SCHEMBL9046020 | 0.78 | TAAR1 (0.36) | TAAR1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL3115865 | 0.77 | TAAR1 (0.70) | TAAR1GAAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9047171 | 0.77 | TAAR1 (0.35) | TAAR1SMN1; SMN2KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | disclosed |