Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046887 | 0.82 | TAAR1 (0.39) | TAAR1LMNAAKR1B1POLBKDM4E | |
| SCHEMBL9044851 | 0.82 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL9045669 | 0.79 | TAAR1 (0.58) | TAAR1POLBKDM4EHTTSMN1; SMN2 | |
| SCHEMBL9046829 | 0.79 | EED (0.40) | TAAR1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL18419803 | 0.79 | MEN1 (0.43) | TAAR1ALDH1A1HSD11B1POLBKDM4E | |
| SCHEMBL9046020 | 0.78 | TAAR1 (0.36) | TAAR1AKR1B1POLBKDM4ENPSR1 | |
| SCHEMBL9048337 | 0.78 | GABRA1 (0.42) | TAAR1ALDH1A1LMNA | |
| SCHEMBL9046158 | 0.77 | GABRA1 (0.42) | TAAR1ALDH1A1LMNAGLASMN1; SMN2 | |
| SCHEMBL9045166 | 0.77 | GABRA1 (0.33) | — | |
| SCHEMBL9047171 | 0.77 | TAAR1 (0.35) | TAAR1LMNAAKR1B1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | disclosed |