Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047243 | 0.82 | NOS1 (0.34) | KDM4ESMN1; SMN2CYP2D6LIMK1NOS1 | |
| SCHEMBL9099497 | 0.77 | NOS1 (0.44) | SMN1; SMN2NOS1ALDH1A1HPGDALOX15 | |
| SCHEMBL9426491 | 0.77 | ADORA3 (0.44) | NOS1ALDH1A1HPGDALOX15ADORA3 | |
| SCHEMBL9046922 | 0.75 | NOS1 (0.36) | NOS1HSP90AA1ALDH1A1HPGDALOX15 | |
| SCHEMBL9097930 | 0.75 | CYP2E1 (0.32) | SMN1; SMN2CYP2A6CYP3A4CYP2E1CYP2C9 | |
| SCHEMBL8940793 | 0.73 | NOS1 (0.34) | KDM4ESMN1; SMN2LIMK1PIK3CDPIK3CA | |
| SCHEMBL9427020 | 0.73 | PDPK1 (0.31) | LIMK1NOS1HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL9098247 | 0.72 | ADORA3 (0.36) | KDM4ECYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9097435 | 0.71 | KDM4E (0.37) | KDM4ESMN1; SMN2CYP3A4CYP2D6HSP90AA1 | |
| SCHEMBL11396640 | 0.70 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2CYP2A6CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412404-B1 | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-01-31 | — | — | EP | disclosed |
| CN-1027370-C | Process for preparing thiazole derivatives | FUJISAWA FARMACEUTICAL CO LTD (JP) | 1995-01-11 | — | — | CN | disclosed |
| US-5369107-A | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5256675-A | Antirheumatic agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-26 | — | — | US | disclosed |
| CN-1049337-A | Thiazole derivative prepares their method, and the medicinal compositions that contains them | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-02-20 | — | — | CN | disclosed |
| EP-0412404-A2 | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-13 | — | — | EP | disclosed |