Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046024 | 0.81 | FAAH (0.51) | FAAHCNR1CNR2 | |
| SCHEMBL1037280 | 0.79 | FAAH (0.56) | FAAHCNR1CNR2MEN1KMT2A | |
| SCHEMBL11346449 | 0.79 | FAAH (0.56) | FAAHCNR1CNR2ALDH1A1ALOX15 | |
| SCHEMBL7264660 | 0.78 | FAAH (0.54) | FAAHCNR1CNR2ALDH1A1ALOX15 | |
| SCHEMBL11154007 | 0.74 | FAAH (0.65) | FAAHCNR1CNR2TSHR | |
| SCHEMBL9668515 | 0.74 | FAAH (0.51) | FAAHCNR1CNR2TSHR | |
| SCHEMBL9048648 | 0.74 | FAAH (0.41) | FAAHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL9049144 | 0.73 | FAAH (0.50) | FAAHCNR1CNR2 | |
| SCHEMBL27833074 | 0.73 | — | — | |
| SCHEMBL9047105 | 0.72 | FAAH (0.53) | FAAHCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115770-B2 | Thiazole Derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-06-19 | — | — | EP | disclosed |
| US-4695639-A | Thiazole derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-09-22 | — | — | US | disclosed |
| EP-0115770-B1 | THIAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1987-07-22 | — | — | EP | disclosed |
| EP-0115770-A1 | Thiazole Derivatives | Takeda Chemical Industries, Ltd. (JP) | 1984-08-15 | — | — | EP | disclosed |