Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28617660 | 0.77 | ALDH1A1 (0.43) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EGAA | |
| SCHEMBL9427630 | 0.74 | LMNA (0.42) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EGAA | |
| SCHEMBL9045868 | 0.74 | FAAH (0.50) | FAAHALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL9045030 | 0.73 | LMNA (0.48) | FAAHSMN1; SMN2ALDH1A1LMNATSHR | |
| SCHEMBL9512744 | 0.73 | CRHBP (0.51) | FAAHSMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL465266 | 0.73 | LMNA (0.41) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EGAA | |
| SCHEMBL10767133 | 0.71 | TSHR (0.52) | SMN1; SMN2ALDH1A1LMNAPOLBTSHR | |
| SCHEMBL9046024 | 0.71 | FAAH (0.51) | FAAH | |
| SCHEMBL8896301 | 0.70 | L3MBTL1 (0.42) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EGAA | |
| SCHEMBL9422948 | 0.70 | POLB (0.45) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115770-B2 | Thiazole Derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-06-19 | — | — | EP | disclosed |
| US-4695639-A | Thiazole derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-09-22 | — | — | US | disclosed |
| EP-0115770-B1 | THIAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1987-07-22 | — | — | EP | disclosed |
| EP-0115770-A1 | Thiazole Derivatives | Takeda Chemical Industries, Ltd. (JP) | 1984-08-15 | — | — | EP | disclosed |