Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 6/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ARG1 | P05089 | 1/20 | 0.40 |
| ▸ | ARG2 | P78540 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5577579 | 0.86 | TAAR1 (0.59) | TAAR1SLC6A2MAOAKIF11LOXL2 | |
| SCHEMBL17351151 | 0.84 | SLC6A2 (0.52) | TAAR1SLC6A2CYP2D6LMNASMN1; SMN2 | |
| SCHEMBL27565318 | 0.84 | SLC6A2 (0.52) | TAAR1SLC6A2CYP2D6LMNASMN1; SMN2 | |
| Water SCHEMBL4443337 | 0.82 | SLC6A2 (0.50) | TAAR1SLC6A2CYP2D6LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5427418 | 0.82 | SLC6A2 (0.50) | TAAR1SLC6A2CYP2D6LMNASMN1; SMN2 | |
| SCHEMBL27435270 | 0.81 | TAAR1 (0.48) | TAAR1SLC6A2MAOAKIF11LOXL2 | |
| SCHEMBL15638016 | 0.81 | TAAR1 (0.57) | TAAR1SLC6A2KIF11LOXL2CYP2D6 | |
| SCHEMBL7491955 | 0.81 | MAOA (0.52) | TAAR1SLC6A2MAOAKIF11LOXL2 | |
| SCHEMBL20683425 | 0.80 | ARG1 (0.64) | TAAR1SLC6A2SMN1; SMN2HIF1AARG1 | |
| SCHEMBL516033 | 0.80 | TAAR1 (0.73) | TAAR1SLC6A2MAOALOXL2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0742216-A2 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1996-11-13 | — | — | EP | disclosed |
| EP-0677516-A1 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-5292735-A | Cyclic amide derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| EP-0468187-A2 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1992-01-29 | — | — | EP | disclosed |