Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 7/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.42 |
| ▸ | GSK3B | P49841 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377463 | 0.94 | TOP2A (0.40) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL6216986 | 0.90 | MEN1 (0.46) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL10377398 | 0.90 | TOP2A (0.40) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL10376042 | 0.90 | MEN1 (0.39) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL6216507 | 0.86 | TOP2A (0.39) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL8131150 | 0.85 | MEN1 (0.39) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL6213897 | 0.85 | GSK3B (0.49) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL9050194 | 0.84 | MEN1 (0.44) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL9416480 | 0.83 | TOP2A (0.43) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL9234562 | 0.82 | MEN1 (0.37) | TOP2ATOP2BGSK3BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588166-B1 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1996-06-05 | — | — | EP | disclosed |
| EP-0588166-A2 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1994-03-23 | — | — | EP | disclosed |
| EP-0391132-A1 | 5-Alkylquinolinone carboxylic acids | BAYER AG (DE) | 1990-10-10 | — | — | EP | disclosed |