Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8145269 | 0.83 | SIGMAR1 (0.48) | SIGMAR1PLD1HTR7L3MBTL1ALDH1A1 | |
| SCHEMBL27432858 | 0.80 | SIGMAR1 (0.51) | SIGMAR1PLD1HTR2AHTR2CHTR2B | |
| SCHEMBL8134785 | 0.80 | SIGMAR1 (0.42) | SIGMAR1PLD1HTR7HTR2AHTR2C | |
| SCHEMBL6190053 | 0.76 | SIGMAR1 (0.43) | SIGMAR1PLD1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL2900748 | 0.76 | PLD1 (0.42) | SIGMAR1PLD1HTR7HTR2AHTR2C | |
| SCHEMBL4498844 | 0.75 | SIGMAR1 (0.41) | SIGMAR1PLD1HTR7HTR2AHTR2C | |
| SCHEMBL31232802 | 0.73 | PLD1 (0.42) | SIGMAR1PLD1HTR7HTR2AHTR2C | |
| SCHEMBL9579077 | 0.72 | SIGMAR1 (0.45) | SIGMAR1ALDH1A1TSHRKDM4EHSD17B10 | |
| SCHEMBL1964149 | 0.72 | PLD1 (0.40) | SIGMAR1PLD1HTR7HTR2AHTR2C | |
| SCHEMBL4563400 | 0.69 | PLD1 (0.40) | SIGMAR1PLD1HTR7HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556329-B1 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5270312-A | Substituted piperazines as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1993-12-14 | — | — | US | disclosed |