Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.35 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5321655 | 0.82 | RIPK1 (0.40) | SIGMAR1PLD1RIPK1BTKKDM4E | |
| SCHEMBL1109657 | 0.80 | SIGMAR1 (0.41) | SIGMAR1RIPK1ALDH1A1HSD17B10 | |
| SCHEMBL8145269 | 0.79 | SIGMAR1 (0.48) | SIGMAR1PLD1ALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7293029 | 0.79 | SIGMAR1 (0.40) | SIGMAR1 | |
| SCHEMBL4498844 | 0.79 | SIGMAR1 (0.41) | SIGMAR1PLD1RIPK1ALDH1A1 | |
| SCHEMBL8134785 | 0.78 | SIGMAR1 (0.42) | SIGMAR1PLD1RIPK1BTKNR3C2 | |
| SCHEMBL16796971 | 0.77 | RIPK1 (0.40) | SIGMAR1PLD1RIPK1BTKCHRNB2 | |
| SCHEMBL31232802 | 0.76 | PLD1 (0.42) | SIGMAR1PLD1ALDH1A1KMT2A | |
| SCHEMBL8499875 | 0.76 | RIPK1 (0.40) | SIGMAR1PLD1RIPK1KDM4EHSD17B10 | |
| SCHEMBL9047401 | 0.76 | SIGMAR1 (0.44) | SIGMAR1PLD1ALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-A4 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1465631-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI Pharmaceuticals, Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003053366-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARMACEUTICALS, INC. (US) | 2003-07-03 | — | — | WO | disclosed |