Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046222 | 0.86 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL9047342 | 0.86 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL9471896 | 0.81 | ALDH1A1 (0.34) | MEN1KMT2AGRM5 | |
| SCHEMBL9045445 | 0.71 | ADORA1 (0.38) | PDGFRBKDR | |
| SCHEMBL9471499 | 0.71 | KDM4E (0.37) | MEN1KMT2AGRM5 | |
| SCHEMBL9471259 | 0.71 | KMT2A (0.37) | MEN1KMT2AGRM5 | |
| SCHEMBL9480388 | 0.70 | KMT2A (0.37) | MEN1KMT2AGRM5 | |
| SCHEMBL17525786 | 0.60 | CYP19A1 (0.43) | GRM5PDGFRBKDR | |
| SCHEMBL22779082 | 0.59 | GRM5 (0.48) | MEN1KMT2AGRM5 | |
| SCHEMBL4457730 | 0.58 | GRM5 (0.64) | MEN1KMT2AGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432677-B1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-03-06 | — | — | EP | disclosed |
| US-5344932-A | N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives | TRUSTEES OF PRINCETON UNIVERSITY (US) | 1994-09-06 | — | — | US | disclosed |
| US-5248775-A | Pyrrolo(2,3-d)pyrimidines | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1993-09-28 | — | — | US | disclosed |
| EP-0432677-A1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-19 | — | — | EP | disclosed |
| US-4996206-A | Antitumor agent | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-02-26 | — | — | US | disclosed |