Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8588226 | 0.98 | TAAR1 (0.48) | TAAR1MAOBIDO1LOXL2AOC3 | |
| SCHEMBL9335133 | 0.98 | TAAR1 (0.48) | TAAR1MAOBIDO1LOXL2AOC3 | |
| SCHEMBL386493 | 0.93 | TAAR1 (0.52) | TAAR1MAOBIDO1LOXL2AOC3 | |
| SCHEMBL10574057 | 0.87 | TAAR1 (0.62) | TAAR1MAOBIDO1LOXL2AOC3 | |
| SCHEMBL755085 | 0.85 | TAAR1 (0.59) | TAAR1MAOBIDO1LOXL2AOC3 | |
| SCHEMBL10571903 | 0.85 | TAAR1 (0.59) | TAAR1MAOBIDO1LOXL2AOC3 | |
| SCHEMBL7545271 | 0.82 | TAAR1 (0.56) | TAAR1MAOBIDO1LOXL2AOC3 | |
| SCHEMBL2320532 | 0.82 | TAAR1 (0.62) | TAAR1MAOBIDO1LOXL2AOC3 | |
| SCHEMBL1287203 | 0.81 | TAAR1 (0.50) | TAAR1MAOBIDO1LOXL2AOC3 | |
| SCHEMBL8498563 | 0.79 | TAAR1 (0.48) | TAAR1MAOBIDO1LOXL2AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582701-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011160084-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2011-12-22 | — | — | WO | disclosed |
| EP-0526342-B1 | Isoquinolin-5yl-sulphonamides, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1996-12-04 | — | — | EP | disclosed |
| US-5208243-A | Analgesics | ADIR ET COMPAGNIE (FR) | 1993-05-04 | — | — | US | disclosed |
| EP-0526342-A1 | Isoquinolin-5yl-sulphonamides, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-02-03 | — | — | EP | disclosed |