Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | APP | P05067 | 2/20 | 0.50 |
| ▸ | SNCA | P37840 | 2/20 | 0.50 |
| ▸ | CTRC | Q99895 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321763 | 0.83 | MAPT (0.72) | MAPTAPPSNCACTRCRAF1 | |
| SCHEMBL9044907 | 0.81 | MAPT (0.46) | MAPTAPPSNCACTRCRAF1 | |
| SCHEMBL9043235 | 0.81 | CTRC (0.48) | MAPTAPPSNCACTRCRAF1 | |
| SCHEMBL9044610 | 0.81 | MAPT (0.42) | MAPTAPPSNCACTRCRAF1 | |
| SCHEMBL9044710 | 0.79 | MAPT (0.46) | MAPTAPPSNCACTRCRAF1 | |
| SCHEMBL9044361 | 0.74 | MAPT (0.40) | MAPTAPPSNCACTRCRAF1 | |
| SCHEMBL8319381 | 0.73 | APP (0.49) | MAPTAPPSNCACTRCRAF1 | |
| SCHEMBL19411582 | 0.70 | MAPT (0.56) | MAPTAPPSNCACTRCRAF1 | |
| SCHEMBL19411581 | 0.70 | MAPT (0.56) | MAPTAPPSNCACTRCRAF1 | |
| SCHEMBL8323139 | 0.70 | MAPT (0.46) | MAPTAPPSNCACTRCRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741726-A1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-11-13 | — | — | EP | disclosed |