Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2916919 | 1.00 | SLC1A2 (0.47) | SLC1A2AKR1C3AKR1C1TSHRSLC18A3 | |
| SCHEMBL4780390 | 1.00 | SLC1A2 (0.47) | SLC1A2AKR1C3AKR1C1TSHRSLC18A3 | |
| SCHEMBL16579321 | 0.89 | MEN1 (0.50) | AKR1C3AKR1C1TSHRMEN1KMT2A | |
| SCHEMBL26303505 | 0.87 | TSHR (0.42) | SLC1A2TSHRSLC18A3SIGMAR1GBA1 | |
| SCHEMBL24203568 | 0.86 | TSHR (0.41) | SLC1A2TSHRSLC18A3SIGMAR1GBA1 | |
| SCHEMBL29711804 | 0.86 | TSHR (0.41) | SLC1A2TSHRSLC18A3SIGMAR1GBA1 | |
| SCHEMBL22072962 | 0.86 | TSHR (0.41) | SLC1A2TSHRSLC18A3SIGMAR1GBA1 | |
| SCHEMBL9045734 | 0.82 | CHRNB2 (0.57) | MEN1KMT2AMAPT | |
| SCHEMBL9344619 | 0.82 | CHRNB2 (0.57) | MEN1KMT2AMAPT | |
| SCHEMBL8262931 | 0.82 | SLC6A2 (0.49) | TSHRMAPTPKMSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549407-B1 | Novel pyrrolidine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1996-09-25 | — | — | EP | disclosed |
| EP-0715623-A1 | PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1996-06-12 | — | — | EP | disclosed |
| US-5296494-A | Pyrrolidine compounds having thromboxane A2 receptor antagonistic activity and thromboxane A2 synthase inhibiting activity | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| EP-0549407-A1 | Novel pyrrolidine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-06-30 | — | — | EP | disclosed |