Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 8/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.41 |
| ▸ | CHRNG | P07510 | 1/20 | 0.41 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9344619 | 1.00 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNA7KDM4EALDH1A1 | |
| SCHEMBL31614673 | 0.92 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNA7KDM4EALDH1A1 | |
| SCHEMBL30233685 | 0.88 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNA7KDM4EALDH1A1 | |
| SCHEMBL2916919 | 0.82 | SLC1A2 (0.47) | MEN1KMT2AMAPT | |
| SCHEMBL4780390 | 0.82 | SLC1A2 (0.47) | MEN1KMT2AMAPT | |
| SCHEMBL9047769 | 0.82 | SLC1A2 (0.47) | MEN1KMT2AMAPT | |
| SCHEMBL30361419 | 0.78 | CHRNB2 (0.64) | CHRNB2CHRNA4CHRNA7MEN1CYP2D6 | |
| SCHEMBL30361535 | 0.78 | CHRNB2 (0.64) | CHRNB2CHRNA4CHRNA7MEN1CYP2D6 | |
| SCHEMBL9354433 | 0.77 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNA7KDM4EALDH1A1 | |
| SCHEMBL17474488 | 0.74 | KDM1A (0.48) | CHRNB2CHRNA4CHRNA7KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549407-B1 | Novel pyrrolidine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1996-09-25 | — | — | EP | disclosed |
| EP-0549407-A1 | Novel pyrrolidine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-06-30 | — | — | EP | disclosed |