Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.62 |
| ▸ | LOXL2 | Q9Y4K0 | 13/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1062382 | 0.83 | ADORA3 (0.75) | ADORA3SLC6A3LOXL2LOXKCNH2 | |
| Thiazolsulfone SCHEMBL152559 | 0.77 | ADORA3 (1.00) | ADORA3SLC6A3LOXL2TSHRLOX | |
| SCHEMBL9232776 | 0.75 | NAPRT (0.68) | NAPRTKDM4ENAMPT | |
| SCHEMBL31404866 | 0.75 | NAPRT (0.68) | NAPRTKDM4ENAMPT | |
| SCHEMBL9046843 | 0.75 | ADORA3 (0.57) | ADORA3SLC6A3LOXL2LOXKCNH2 | |
| SCHEMBL9098224 | 0.74 | ADORA3 (0.57) | ADORA3SLC6A3LOXL2MAPTKDM4E | |
| SCHEMBL5875692 | 0.74 | ADORA3 (0.76) | ADORA3SLC6A3LOXL2MAPTKDM4E | |
| SCHEMBL8903789 | 0.73 | LOX (0.56) | ADORA3SLC6A3LOXL2KDM4ELOX | |
| SCHEMBL8866219 | 0.71 | HTR6 (0.59) | ADORA3SLC6A3NAPRTTSHRNAMPT | |
| SCHEMBL1062638 | 0.71 | ADORA3 (0.69) | ADORA3SLC6A3MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412404-B1 | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-01-31 | — | — | EP | disclosed |
| US-5369107-A | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5256675-A | Antirheumatic agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-26 | — | — | US | disclosed |
| EP-0412404-A2 | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-13 | — | — | EP | disclosed |