Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049066 | 0.83 | ALOX5 (0.47) | FFAR1FFAR4 | |
| SCHEMBL9367947 | 0.79 | ALOX5 (0.44) | KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9049626 | 0.76 | ALOX5 (0.45) | KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9048409 | 0.76 | ALOX5 (0.53) | FFAR1 | |
| SCHEMBL21494233 | 0.73 | SMN1; SMN2 (0.44) | FFAR1FFAR4TSHRKMT2ACYP2D6 | |
| SCHEMBL16344430 | 0.71 | FFAR1 (0.42) | FFAR1FFAR4TSHRKMT2ACYP2D6 | |
| SCHEMBL16673114 | 0.70 | FFAR1 (0.43) | FFAR1FFAR4TSHRKMT2AMEN1 | |
| SCHEMBL27416780 | 0.70 | FFAR1 (0.41) | FFAR1FFAR4TSHRKMT2ACYP2D6 | |
| SCHEMBL27416779 | 0.70 | FFAR1 (0.41) | FFAR1FFAR4TSHRKMT2ACYP2D6 | |
| SCHEMBL9048880 | 0.69 | ALOX5 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |