SCHEMBL9048632

SCHEMBL9048632

CC(C#CCc1cccc(Oc2ccccc2)c1)N(O)C(N)=O

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 16/20 0.69
ACACB O00763 1/20 0.53
ACACA Q13085 1/20 0.53
PTGES O14684 1/20 0.47
EPHX2 P34913 3/20 0.43
MAPT P10636 2/20 0.43
MEN1 O00255 1/20 0.43
ALDH1A1 P00352 1/20 0.43
TP53 P04637 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
HPGD P15428 1/20 0.43
ALOX15 P16050 1/20 0.43
TSHR P16473 1/20 0.43
ALOX12 P18054 1/20 0.43
NFKB1 P19838 1/20 0.43
MAPK1 P28482 1/20 0.43
CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9054816 0.87 ALOX5 (0.61) ALOX5ACACBACACAPTGESMAPT
SCHEMBL9047289 0.86 ALOX5 (0.60) ALOX5ACACBACACAPTGESEPHX2
SCHEMBL9048880 0.85 ALOX5 (0.52) ALOX5ACACBACACAEPHX2
SCHEMBL9048427 0.84 ALOX5 (0.66) ALOX5ACACBACACAEPHX2MAPT
SCHEMBL9046388 0.82 ALOX5 (1.00) ALOX5ACACBACACAEPHX2
SCHEMBL8782568 0.81 ALOX5 (0.62) ALOX5EPHX2ALDH1A1LMNA
SCHEMBL9048203 0.78 ALOX5 (0.79) ALOX5ACACBACACAEPHX2
SCHEMBL9046472 0.76 ALOX5 (0.58) ALOX5ACACBACACAEPHX2
SCHEMBL9049644 0.76 ALOX5 (0.48) ALOX5ACACBACACAEPHX2
SCHEMBL9054814 0.76 ALOX5 (0.65) ALOX5ACACBACACAEPHX2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0540673-B1 ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY ABBOTT LAB (US) 1996-10-16 EP claimed
EP-0540673-A4 1994-04-27 EP claimed
EP-0540673-A1 ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. ABBOTT LAB (US) 1993-05-12 EP claimed
WO-1992001682-A1 ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY ABBOTT LABORATORIES (US) 1992-02-06 WO claimed
EP-0540673-B1 ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY ABBOTT LAB (US) 1996-10-16 EP disclosed
US-5559144-A LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES ABBOTT LABORATORIES (US) 1996-09-24 US disclosed
US-5476873-A Inhibit biosynthesis of leukotrienes ABBOTT LABORATORIES (US) 1995-12-19 US disclosed
EP-0540673-A4 1994-04-27 EP disclosed
EP-0540673-A1 ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. ABBOTT LAB (US) 1993-05-12 EP disclosed
WO-1992001682-A1 ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY ABBOTT LABORATORIES (US) 1992-02-06 WO disclosed