Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.66 |
| ▸ | ACACB | O00763 | 1/20 | 0.53 |
| ▸ | ACACA | Q13085 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9048582 | 0.91 | ALOX5 (0.55) | ALOX5ACACBACACAHTR1DHTR1B | |
| SCHEMBL9046472 | 0.89 | ALOX5 (0.58) | ALOX5ACACBACACAEPHX2 | |
| SCHEMBL9049762 | 0.87 | ALOX5 (0.51) | ALOX5ACACBACACAHTR1DHTR1B | |
| SCHEMBL9047113 | 0.87 | ALOX5 (0.51) | ALOX5ACACBACACALMNATDP1 | |
| SCHEMBL9054816 | 0.84 | ALOX5 (0.61) | ALOX5ACACBACACAALDH1A1MAPT | |
| SCHEMBL9048632 | 0.84 | ALOX5 (0.69) | ALOX5ACACBACACAALDH1A1MAPT | |
| SCHEMBL8782568 | 0.81 | ALOX5 (0.62) | ALOX5ALDH1A1SMN1; SMN2LMNAEPHX2 | |
| SCHEMBL9046388 | 0.80 | ALOX5 (1.00) | ALOX5ACACBACACAEPHX2 | |
| SCHEMBL9047289 | 0.79 | ALOX5 (0.60) | ALOX5ACACBACACAALDH1A1MAPT | |
| SCHEMBL9049640 | 0.78 | ALOX5 (0.67) | ALOX5HTR1DHTR1BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |