Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ADK | P55263 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3257778 | 0.95 | PDE4A (0.46) | CYP1A2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16461405 | 0.85 | LMNA (0.47) | CYP1A2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23042295 | 0.82 | LCK (0.45) | CYP1A2ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4063214 | 0.81 | MAPT (0.47) | CYP1A2ALDH1A1ADKLMNASMN1; SMN2 | |
| SCHEMBL4840266 | 0.81 | KDM4E (0.50) | CYP1A2SRCADKNPSR1MAP4K4 | |
| SCHEMBL9045424 | 0.77 | SMN1; SMN2 (0.50) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL4065247 | 0.77 | ADK (0.44) | ALDH1A1ADKNPSR1TDP1LMNA | |
| SCHEMBL999683 | 0.77 | MAPT (0.50) | CYP1A2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9046895 | 0.77 | LMNA (0.51) | CYP1A2LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31626660 | 0.76 | MEN1 (0.61) | CYP1A2ALDH1A1ADKLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |