Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 6/20 | 0.37 |
| ▸ | LDHB | P07195 | 6/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ACP3 | P15309 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604874 | 0.76 | LDHA (0.42) | LDHALDHBOPRM1OPRL1CYP3A4 | |
| SCHEMBL6605852 | 0.68 | LDHA (0.41) | LDHALDHBLMNANPSR1HSD11B1 | |
| SCHEMBL9026061 | 0.68 | LDHA (0.43) | LDHALDHBOPRM1OPRD1OPRK1 | |
| SCHEMBL6172935 | 0.66 | KDM4E (0.30) | — | |
| SCHEMBL6175498 | 0.65 | LDHA (0.34) | LDHAOPRD1ALDH1A1 | |
| SCHEMBL6603297 | 0.62 | LDHA (0.58) | LDHALDHB | |
| SCHEMBL6604700 | 0.62 | LDHA (0.58) | LDHALDHB | |
| SCHEMBL7441906 | 0.62 | LDHA (0.38) | LDHALDHB | |
| SCHEMBL6604488 | 0.62 | LDHA (0.52) | LDHALDHBOPRM1OPRD1ALDH1A1 | |
| SCHEMBL6174563 | 0.62 | LDHA (0.35) | LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729464-A1 | 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | claimed |
| EP-0729464-A1 | 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |